Engineered transmembrane pores
نویسندگان
چکیده
منابع مشابه
Ion transport across transmembrane pores.
To study the pore-mediated transport of ionic species across a lipid membrane, a series of molecular dynamics simulations have been performed of a dipalmitoyl-phosphatidyl-choline bilayer containing a preformed water pore in the presence of sodium and chloride ions. It is found that the stability of the transient water pores is greatly reduced in the presence of the ions. Specifically, the bind...
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Human LL-37 is a multifunctional cathelicidin peptide that has shown a wide spectrum of antimicrobial activity by permeabilizing microbial membranes similar to other antimicrobial peptides; however, its molecular mechanism has not been clarified. Two independent experiments revealed LL-37 bound to membranes in the α-helical form with the axis lying in the plane of membrane. This led to the conc...
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Calcium-triggered exocytotic release of neurotransmitters and hormones from neurons and neuroendocrine cells underlies neuronal communication, motor activity and endocrine functions. The core of the neuronal exocytotic machinery is composed of soluble N-ethyl maleimide sensitive factor attachment protein receptors (SNAREs). Formation of complexes between vesicle-attached v- and plasma-membrane ...
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A variety of natural and synthetic compounds are known to selfassemble to give transmembrane ion channels.1 Hydrogen-bonded macrocycles that can π-stack are a new type of channel motif.2 Thus, folate quartets stack to give ion channels in lipid bilayers.3 This folate assembly had a single-channel conductance of 10-20 picosiemens (pS), values consistent with the quartet’s 3 Å diameter. We found ...
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The synthetic biology toolbox lacks extendable and conformationally controllable yet easy-to-synthesize building blocks that are long enough to span membranes. To meet this need, an iterative synthesis of α-aminoisobutyric acid (Aib) oligomers was used to create a library of homologous rigid-rod 310-helical foldamers, which have incrementally increasing lengths and functionalizable N- and C-ter...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2016
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2016.08.005